Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization zuo2020alterations

The author measured SARS-CoV-2 detected by real-time reverse transcriptase PCR in fecal samples from 15 hospitalized COVID-19 patients in Hong Kong.

Analytes

stool_SARSCoV2_SymptomOnset

SARS-CoV-2 RNA gene copy concentrations in fecal samples, which were were collected 2 to 3 times per week starting from hospital admission, and SARS-CoV-2 detection in feces was tracked longitudinally. The day is calculated relative to the date of symptom onset. The concentrations were quantified in gene copies per mL.

exponential for stool_SARSCoV2_SymptomOnset

Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.

Biomarker: SARS-CoV-2
Specimen: stool
Units: gc/mL
Gene target: N1
Participants: 12
Negative samples: 21
Positive samples (not quantifiable): 0
Quantifiable samples: 19
Limit of quantification: unknown
Limit of detection: 347

stool_SARSCoV2_ConfirmationDate

SARS-CoV-2 RNA gene copy concentrations in fecal samples, which were were collected 2 to 3 times per week starting from hospital admission, and SARS-CoV-2 detection in feces was tracked longitudinally. The day is calculated relative to the date of SARS-CoV-2 confirmation. The concentrations were quantified in gene copies per mL.

observations for stool_SARSCoV2_ConfirmationDate

Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.

Biomarker: SARS-CoV-2
Specimen: stool
Units: gc/mL
Gene target: N1
Participants: 3
Negative samples: 5
Positive samples (not quantifiable): 0
Quantifiable samples: 7
Limit of quantification: unknown
Limit of detection: 347