Detection of fecal shedding of rotavirus vaccine in infants following their first dose of pentavalent rotavirus vaccine yen2011detection

This study, conducted between May 2008 and February 2009 at the Broadway Practice of the Ambulatory Care Network of New York-Presbyterian Hospital, examined fecal shedding of the pentavalent rotavirus vaccine (RV5) in infants aged 6 to 12 weeks following their first dose. The study involved 198 enrolled infants, with 103 returning stool collection kits. Rotavirus antigen was detected in 21.4% of the kits. The study used enzyme immunoassay (EIA) and RT-PCR to detect vaccine-type rotavirus in stool samples collected over 9 days post-vaccination. The findings suggest potential for horizontal transmission of vaccine virus, particularly in households with immunocompromised individuals.

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