Laboratory Diagnosis and Monitoring the Viral Shedding of SARS-CoV-2 Infection yang2020laboratory

This study involved 3552 clinical samples from 410 COVID-19 patients confirmed by Guangdong CDC. Oropharyngeal swabs, nasopharyngeal swabs and sputum samples were tested for upper respiratory tract infection, while bronchoalveolar lavage fluid (BALF) was tested for lower respiratory tract infection.

Analytes

upper_resp_tract

SARS-CoV-2 RNA ct value from evaluation of upper respiratory tract samples.

gamma for upper_resp_tract

Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.

Biomarker: SARS-CoV-2
Specimen: nasopharyngeal swab, oropharyngeal swab, and sputum
Units: cycle threshold
Gene target: ORF1ab and N gene
Participants: 28
Negative samples: 174
Positive samples (not quantifiable): 0
Quantifiable samples: 102
Limit of quantification: unknown
Limit of detection: 38

lower_resp_tract

SARS-CoV-2 RNA ct value from evaluation of upper respiratory tract samples.

exponential for lower_resp_tract

Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.

Biomarker: SARS-CoV-2
Specimen: bronchoalveolar lavage fluid
Units: cycle threshold
Gene target: ORF1ab and N gene
Participants: 21
Negative samples: 23
Positive samples (not quantifiable): 0
Quantifiable samples: 62
Limit of quantification: unknown
Limit of detection: 38