Fecal viral shedding in COVID-19 patients: Clinical significance, viral load dynamics and survival analysis wang2020fecal
This study investigates the fecal shedding of SARS-CoV-2 in COVID-19 patients, analyzing viral load dynamics, clinical significance, and survival analysis.
Analytes
stool_SARSCoV2_ORF1ab
qPCR analysis of SARS-CoV-2 RNA in stool samples targeting ORF1ab gene. Ct less than 35 is defined as positive, and Ct > 40 is considered as negative.
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.
stool_SARSCoV2_N
qPCR analysis of SARS-CoV-2 RNA in stool samples targeting N gene. Ct = 35 is the cut-off for a positive result, and Ct = 40 is a negative sample.
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.