Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case Series vetter2020daily

The author measured SARS-CoV-2 detected by real-time reverse transcriptase PCR in both oropharyngeal (OPS) and nasopharyngeal (NPS) swabs from five COVID-19 patients in Geneva, Switzerland, up to days 7 and 19 after symptom onset. Cellular and humoral SARS-CoV-2-specific adaptive responses and serology data are currently not included in this dataset.

Analytes

NPS_SARSCoV2

SARS-CoV-2 RNA gene copy concentrations in nasopharyngeal samples. The concentrations were quantified in gene copies per mL.

gamma shifted for NPS_SARSCoV2

Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.

Biomarker: SARS-CoV-2
Specimen: nasopharyngeal swab
Units: gc/mL
Gene target: unknown
Participants: 5
Negative samples: 2
Positive samples (not quantifiable): 0
Quantifiable samples: 37
Limit of quantification: unknown
Limit of detection: unknown

OPS_SARSCoV2

SARS-CoV-2 RNA gene copy concentrations in oropharyngeal samples. The concentrations were quantified in gene copies per mL.

gamma for OPS_SARSCoV2

Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.

Biomarker: SARS-CoV-2
Specimen: oropharyngeal swab
Units: gc/mL
Gene target: unknown
Participants: 5
Negative samples: 1
Positive samples (not quantifiable): 0
Quantifiable samples: 34
Limit of quantification: unknown
Limit of detection: unknown