Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients tan2021early
Measured SARS-CoV-2 viral load in the upper respiratory tract, along with SARS-CoV-2-specific antibodies and T cell responses, at multiple time points from acute infection through convalescence or until death.
Analytes
swab_SARSCoV2_N
The swab_SARSCoV2_N analyte refers to the detection of SARS-CoV-2 RNA in patient oropharyngeal swabs, using RT-PCR cycle threshold (CT) values to calculate the relative quantities of SARS-CoV-2 RNA. 10^(-11) was the detection limit, which was transformed as CT value equals 36.5. Data was obtained from the combined dataset in the supplementary materials of Challenger et al. (2022)
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.