Clinical features and outcomes of influenza infections in lung transplant recipients: a single-season cohort study schuurmans2014clinical
Retrospective single-season (2010/2011) cohort study of lung transplant recipients at Zurich University Hospital. Laboratory-confirmed influenza A or B infections (22 infections in 21 patients) were diagnosed by nasopharyngeal swab and real-time RT-PCR. Patients received empirical oseltamivir and serial weekly swabs were performed until virologic results were negative. Study reports Ct values from nasopharyngeal swabs (used here as cycle-threshold measurements relative to symptom onset). Prolonged viral shedding (>=7 days) was common.
Analytes
nasopharyngeal_swab_influenza_CT
Real-time RT-PCR cycle threshold (Ct) values measured on nasopharyngeal swab specimens for detection of influenza virus (reported by the study as PCR Ct values from diagnostic qRT-PCR of nasopharyngeal swabs).
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.