Viral dynamics of the Respiratory Syncytial Virus during experimental human challenge: insights for transmission and protection schumer2026viral
Human RSV challenge study in adults analyzing high-resolution viral kinetics using mathematical models. Figure-derived CSV data provide RSV RNA concentrations (gc/mL) and infectious virus titers (pfu/mL) over days post-exposure for individual participants (PatientID). The study report the specimen as nasal samples, and we consider these to be nasopharyngeal aspirates based on the methods description. The study does not provide assay details for the viral RNA or infectious virus measurements.
Analytes
gc_ml
RSV viral RNA concentration quantified from respiratory samples; values provided as gene copies per mL (gc/mL) from figure-derived CSV. Assay method/gene target not provided in the supplied text/CSV.
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.
pfu_ml
RSV infectious virus titer measured as plaque forming units per mL (pfu/mL) from figure-derived CSV. Assay method not provided in the supplied text/CSV.
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.