Different drug-resistant influenza A(H3N2) variants in two immunocompromised patients treated with oseltamivir during the 2011–2012 influenza season in Italy piralla2013different
Hospital-based study in Italy during the 2011–2012 influenza season assessing influenza A(H3N2) viral kinetics and emergence of oseltamivir resistance. Sequential respiratory samples were analyzed from treated and untreated patients; neuraminidase (NA) sequencing and clonal analysis were performed in patients unresponsive to oseltamivir, identifying resistant mutations including R292K, E119V, N294S, and Del247–250. Figure-derived quantitative viral load time series are available for multiple patients by immune status and treatment, and Table 1 reports clonal proportions of NA mutations over time for two immunocompromised oseltamivir-unresponsive patients (Pavia/14 and Pavia/27).
Analytes
nasopharyngeal_swab
Quantitative influenza A(H3N2) viral load time series from nasal/nasopharyngeal swabs (NS) as digitized from Fig. 1; values provided as gene-copy concentration (exact PCR target/assay details not provided in the supplied text/CSV). Time is relative to the figure’s reference (not specified in the provided excerpt; CSV provides day values directly).
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.
bronchoalveolar_lavage_fluid
Quantitative influenza A(H3N2) viral load time series from bronchoalveolar lavage (BAL) as digitized from Fig. 1; values provided as gene-copy concentration (exact PCR target/assay details not provided in the supplied text/CSV). Time is relative to the figure’s reference (not specified in the provided excerpt; CSV provides day values directly).
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.