Single base substitutions in the capsid region of the norovirus genome during viral shedding in cases of infection in areas where norovirus infection is endemic obara2008single

This study investigates norovirus (NoV) infections in Toyama Prefecture, Japan, during fiscal year 2006, focusing on viral shedding in feces. The study involved 30 individuals from a local hotel outbreak in May 2006, with stool specimens collected and analyzed using real-time PCR. Two employees exhibited long-term viral shedding, with single base substitutions in the NoV capsid region observed. The study highlights the potential for NoV evolution in the gastrointestinal tract, with genetic changes occurring during the infectious course. The research was supported by a Health Labor Sciences Research Grant from the Japanese Ministry of Health, Labor, and Welfare.

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