Norovirus in symptomatic and asymptomatic individuals: cytokines and viral shedding newman2016norovirus
Human norovirus GI.1 challenge study comparing symptomatic vs asymptomatic infected individuals, relating stool norovirus RNA titers (from prior RT-qPCR quantification) to serum cytokine responses. This extraction contains stool viral shedding measurements (GEC/g) digitized from a figure-data CSV (batch 1/4) for 6 symptomatic participants (PatientID 1-6), with time in days relative to inoculation/challenge (day 0 = prechallenge).
Analytes
gec_g
Stool norovirus GI.1 RNA quantity measured as genome equivalent copies per gram (GEC/g), quantified previously by RT-qPCR; values here are from figure-data CSV for symptomatic participants.
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.