Long-term viral shedding and viral genome mutation in norovirus infection miyoshi2015long

This study investigates the duration of viral shedding in patients from two outbreaks and four sporadic cases of norovirus (NoV) infections. The research highlights the longest period of viral shedding into feces, which was 173 days in an inpatient from one outbreak case. The study also examines the VP1 sequence from two long-term viral shedding cases, revealing several mutations. The findings suggest that the long-term carrier state of norovirus infection contributes to the generation of escape mutants by host immunoselection.

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