Rotavirus vaccine strain transmission by vaccinated infants in the foster home miura2017rotavirus
Prospective surveillance in a foster home setting assessing shedding and transmission of rotavirus vaccine strains. Stool samples were collected and tested by quantitative real-time RT-PCR. The study included 4 RV-vaccinated infants (160 samples) and 23 unvaccinated infants (766 samples). Vaccine-strain RNA was persistently detected in stool from the four vaccine recipients and in one unvaccinated infant (who had been vaccinated prior to enrollment). Quantitative RT-PCR data showed a peak RNA load about 1 week after vaccination followed by gradual decrease. Study suggests limited transmission of vaccine strains in close-contact environment.
Analytes
stool_rotavirus_vaccine_RV1_dose1
Quantitative real-time RT-PCR measuring rotavirus vaccine (RV1) RNA in stool; values reported as PCR cycle threshold (Ct).
Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.
stool_rotavirus_vaccine_RV1_dose2
Quantitative real-time RT-PCR measuring rotavirus vaccine (RV1) RNA in stool; values reported as PCR cycle threshold (Ct).
Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.
stool_rotavirus_vaccine_RV5_dose1
Quantitative real-time RT-PCR measuring rotavirus vaccine (RV5) RNA in stool; values reported as PCR cycle threshold (Ct).
Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.
stool_rotavirus_vaccine_RV5_dose2
Quantitative real-time RT-PCR measuring rotavirus vaccine (RV5) RNA in stool; values reported as PCR cycle threshold (Ct).
Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.
stool_rotavirus_vaccine_RV5_dose3
Quantitative real-time RT-PCR measuring rotavirus vaccine (RV5) RNA in stool; values reported as PCR cycle threshold (Ct).
Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.