Monkeypox-related ophthalmic disease (MPXROD): Monitoring the antiviral effect of tecovirimat with monkeypox virus detection in tear samples mitsios2024monkeypox
Case report of mpox-related ophthalmic disease treated with tecovirimat, monitoring mpox virus (MPXV) detection in tear-wash samples using real-time PCR over time in both eyes (OD and OS). One adult male patient (HIV-positive) had serial tear-wash measurements reported at days 0, 7, 14, and 28 relative to treatment initiation (tecovirimat).
Analytes
od_tear_wash
MPXV-DNA detection in right-eye (OD) tear-wash sample by real-time PCR (RT-PCR) on tear-wash aspirated after instillation of saline onto the ocular surface; values reported as provided in figure-data CSV.
Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.
os_tear_wash
MPXV-DNA detection in left-eye (OS) tear-wash sample by real-time PCR (RT-PCR) on tear-wash aspirated after instillation of saline onto the ocular surface; values reported as provided in figure-data CSV.
Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.