Shedding of porcine circovirus type 1 DNA and rotavirus RNA by infants vaccinated with Rotarix® mijatovicrustempasic2017shedding

This study investigated the shedding of porcine circovirus type 1 (PCV-1) DNA and Rotavirus group A (RVA) RNA in 33 infants aged approximately 2 months following the first dose of Rotarix® vaccine. Stool samples were collected serially post-vaccination and analyzed using molecular methods. The study found that 21% of infants did not shed RVA RNA beyond day 3, suggesting a lack of vaccine virus replication in some cases. The study was conducted in Atlanta, Georgia, and involved both full-term and preterm infants. The analysis used quantitative real-time RT-PCR and qPCR assays to detect viral RNA and DNA in stool samples.

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