Vomiting as a Symptom and Transmission Risk in Norovirus Illness: Evidence from Human Challenge Studies kirby2016vomiting

This study investigates the role of vomiting in norovirus transmission using data from human challenge studies with GI.1 Norwalk virus, GII.2 Snow Mountain virus, and a pilot study with GII.1 Hawaii virus. The study involved healthy adult subjects who were challenged with norovirus and monitored for symptoms, including vomiting. Emesis samples were collected and analyzed for viral titers using strain-specific quantitative RT-PCR. The study found that vomiting is a common symptom in norovirus infection and contributes significantly to environmental contamination and transmission risk. The study provides quantitative data on virus titers in emesis, which is critical for risk assessment and control measures.

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