The human bocavirus role in acute respiratory tract infections of pediatric patients as defined by viral load quantification gerna2007human

Hospital-based study of acute respiratory tract infection patients testing for human bocavirus (HBoV) and other respiratory viruses using PCR, with HBoV DNA quantified in respiratory samples (nasopharyngeal aspirates per abstract). CSV-derived longitudinal/paired measurements are reported relative to either hospital admission or confirmation date for bocavirus and several co-detected respiratory viruses (RSV, rhinovirus, parainfluenza virus, adenovirus, coronavirus). We could not find a DOI for this paper; it is not available.

Analytes

hospital_admission_bocavirus

PCR-based detection/quantification of human bocavirus (HBoV) in respiratory samples; measurements timed relative to hospital admission (day 0 = admission).

observations for hospital_admission_bocavirus

Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.

Biomarker: bocavirus
Specimen: nasopharyngeal aspirate
Units: gc/mL
Gene target: NS1
Participants: 10
Negative samples: 0
Positive samples (not quantifiable): 12
Quantifiable samples: 8
Limit of quantification: 1000
Limit of detection: unknown

hospital_admission_rsv

PCR-based detection/quantification of respiratory syncytial virus (RSV) in respiratory samples; measurements timed relative to hospital admission (day 0 = admission).

exponential for hospital_admission_rsv

Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.

Biomarker: RSV
Specimen: nasopharyngeal aspirate
Units: gc/mL
Participants: 5
Negative samples: 0
Positive samples (not quantifiable): 0
Quantifiable samples: 10
Limit of quantification: 1000
Limit of detection: unknown

hospital_admission_rhinovirus

PCR-based detection/quantification of rhinovirus in respiratory samples; measurements timed relative to hospital admission (day 0 = admission).

observations for hospital_admission_rhinovirus

Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.

Biomarker: rhinovirus
Specimen: nasopharyngeal aspirate
Units: gc/mL
Participants: 4
Negative samples: 0
Positive samples (not quantifiable): 4
Quantifiable samples: 4
Limit of quantification: 1000
Limit of detection: unknown

hospital_admission_parainfluenza_virus

PCR-based detection/quantification of parainfluenza virus in respiratory samples; measurements timed relative to hospital admission (day 0 = admission).

observations for hospital_admission_parainfluenza_virus

Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.

Biomarker: parainfluenza virus
Specimen: nasopharyngeal aspirate
Units: gc/mL
Participants: 1
Negative samples: 0
Positive samples (not quantifiable): 1
Quantifiable samples: 1
Limit of quantification: 1000
Limit of detection: unknown

hospital_admission_adenovirus

PCR-based detection/quantification of adenovirus in respiratory samples; measurements timed relative to hospital admission (day 0 = admission).

observations for hospital_admission_adenovirus

Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.

Biomarker: adenovirus
Specimen: nasopharyngeal aspirate
Units: gc/mL
Participants: 1
Negative samples: 0
Positive samples (not quantifiable): 1
Quantifiable samples: 1
Limit of quantification: 1000
Limit of detection: unknown

confirmation_date_bocavirus

PCR-based detection/quantification of human bocavirus (HBoV) in respiratory samples; measurements timed relative to confirmation date (day 0 = first positive/confirmation).

observations for confirmation_date_bocavirus

Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.

Biomarker: bocavirus
Specimen: nasopharyngeal aspirate
Units: gc/mL
Gene target: NS1
Participants: 42
Negative samples: 0
Positive samples (not quantifiable): 9
Quantifiable samples: 33
Limit of quantification: 1000
Limit of detection: unknown

confirmation_date_rsv

PCR-based detection/quantification of respiratory syncytial virus (RSV) in respiratory samples; measurements timed relative to confirmation date (day 0 = first positive/confirmation).

observations for confirmation_date_rsv

Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.

Biomarker: RSV
Specimen: nasopharyngeal aspirate
Units: gc/mL
Participants: 14
Negative samples: 0
Positive samples (not quantifiable): 2
Quantifiable samples: 13
Limit of quantification: 1000
Limit of detection: unknown

confirmation_date_rhinovirus

PCR-based detection/quantification of rhinovirus in respiratory samples; measurements timed relative to confirmation date (day 0 = first positive/confirmation).

observations for confirmation_date_rhinovirus

Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.

Biomarker: rhinovirus
Specimen: nasopharyngeal aspirate
Units: gc/mL
Participants: 10
Negative samples: 0
Positive samples (not quantifiable): 0
Quantifiable samples: 10
Limit of quantification: 1000
Limit of detection: unknown

confirmation_date_coronavirus

PCR-based detection/quantification of seasonal human coronavirus in respiratory samples; measurements timed relative to confirmation date (day 0 = first positive/confirmation).

observations for confirmation_date_coronavirus

Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.

Biomarker: coronavirus
Specimen: nasopharyngeal aspirate
Units: gc/mL
Participants: 1
Negative samples: 0
Positive samples (not quantifiable): 0
Quantifiable samples: 1
Limit of quantification: 1000
Limit of detection: unknown

confirmation_date_parainfluenza_virus

PCR-based detection/quantification of parainfluenza virus in respiratory samples; measurements timed relative to confirmation date (day 0 = first positive/confirmation).

observations for confirmation_date_parainfluenza_virus

Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.

Biomarker: parainfluenza virus
Specimen: nasopharyngeal aspirate
Units: gc/mL
Participants: 2
Negative samples: 0
Positive samples (not quantifiable): 1
Quantifiable samples: 1
Limit of quantification: 1000
Limit of detection: unknown

confirmation_date_adenovirus

PCR-based detection/quantification of adenovirus in respiratory samples; measurements timed relative to confirmation date (day 0 = first positive/confirmation).

observations for confirmation_date_adenovirus

Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.

Biomarker: adenovirus
Specimen: nasopharyngeal aspirate
Units: gc/mL
Participants: 2
Negative samples: 0
Positive samples (not quantifiable): 0
Quantifiable samples: 2
Limit of quantification: 1000
Limit of detection: unknown