Hydroxychloroquine and azithromycin as a treatment of COVID-19:results of an open-label non-randomized clinical trial gautret2020hydroxychloroquine
This study evaluated the effect of hydroxychloroquine on respiratory viral loads. Six patients were asymptomatic, 22 exhibited upper respiratory tract infection symptoms, and eight showed lower respiratory tract infection symptoms. Only 19 patients with a known onset of symptoms were included in the analysis below. Data for the nasopharyngeal swab results were obtained from the combined dataset in the supplementary materials of Challenger et al. (2022). Attributes of drug treatments were sourced from the supplementary materials of the original paper.
Analytes
nasopharyngeal_swab_SARSCoV2_Ct
Cycle threshold (Ct) values targeting the E gene in nasopharyngeal swab samples.
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.