Viral shedding and susceptibility to oseltamivir in hospitalized immunocompromised patients with influenza in the Influenza Resistance Information Study (IRIS) fraaij2015viral
Observational substudy of the Influenza Resistance Information Study (IRIS) in immunocompromised patients with influenza. Nasal and throat swabs were analysed by RT-PCR on day 1 and then every 3 days until patients were virus-free to assess viral shedding and emergence of oseltamivir resistance (H275Y). Of 42 enrolled patients, 29 were influenza RT-PCR positive on day 1 (18 adults, 11 children). Resistance (H275Y) was detected in some post-baseline samples; clinical and virological outcomes were described.
Analytes
particles_ml
RT-PCR quantification of influenza virus from nasal and throat (nasopharyngeal and oropharyngeal) swabs. Values reported as particles per mL in the source CSV and represented here as virus particles per mL (vp/mL). Genotype (e.g., H, H+Y) was reported per sample in the CSV; gene target not specified in the provided data.
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.