Comparison of quantitative reverse transcription-PCR to viral culture for assessment of respiratory syncytial virus shedding falsey2003comparison
Comparative study of RSV shedding in adult volunteers experimentally challenged with RSV A2, comparing quantitative real-time RT-PCR results with viral culture across multiple postinfection days (0-12 and day 28). CSV-provided measurements represent a time series per subject (PatientID 1-5) with values recorded by day relative to infection/challenge.
Analytes
nasal_respiratory_syncytial_virus_quant_rt_pcr
Quantitative real-time RT-PCR measurement of respiratory syncytial virus (RSV) from respiratory specimens collected in an adult RSV A2 challenge study; numeric values provided in CSV (assay details, gene target, and calibration/units not provided in the supplied text/CSV).
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.