Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children el2011respiratory
Observational study of previously healthy children <2 years old with naturally acquired RSV infection; RSV load in respiratory secretions was measured by fresh quantitative culture over serial hospital days to evaluate viral dynamics and associations with disease severity outcomes (eg, length of hospitalization, ICU requirement, respiratory failure).
Analytes
respiratory_secretions_RSV_viral_load
RSV viral load in respiratory secretions measured by fresh quantitative culture (reported as quantitative values; negatives indicate not detected by culture).
Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.