Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States covid2020clinical

This study describes the first 12 COVID-19 patients identified in the United States, tracking their clinical progression and virological characteristics. SARS-CoV-2 was detected by real-time reverse transcriptase PCR in stool, urine, serum, sputum, oropharyngeal and nasopharyngeal swabs for 2 to 3 weeks after symptom onset. Results were reported in cycle threshold (Ct) values.

Analytes

Stool_SARSCoV2

SARS-CoV-2 RNA gene copy concentration in stool samples. The results were reported in cycle threshold numbers.

Biomarker: SARS-CoV-2
Specimen: stool
Units: cycle threshold
Gene target: N
Participants: 10
Negative samples: 26
Positive samples (not quantifiable): 0
Quantifiable samples: 25
Limit of quantification: unknown
Limit of detection: 40

Serum_SARSCoV2

SARS-CoV-2 RNA gene copy concentration in serum samples. The results were reported in cycle threshold numbers.

Biomarker: SARS-CoV-2
Specimen: serum
Units: cycle threshold
Gene target: N
Participants: 11
Negative samples: 66
Positive samples (not quantifiable): 0
Quantifiable samples: 6
Limit of quantification: unknown
Limit of detection: 40

Sputum_SARSCoV2

SARS-CoV-2 RNA gene copy concentration in sputum samples. The results were reported in cycle threshold numbers.

Biomarker: SARS-CoV-2
Specimen: sputum
Units: cycle threshold
Gene target: N
Participants: 6
Negative samples: 3
Positive samples (not quantifiable): 0
Quantifiable samples: 17
Limit of quantification: unknown
Limit of detection: 40

OPS_SARSCoV2

SARS-CoV-2 RNA gene copy concentration in oropharyngeal samples. The results were reported in cycle threshold numbers.

Biomarker: SARS-CoV-2
Specimen: oropharyngeal swab
Units: cycle threshold
Gene target: N
Participants: 12
Negative samples: 73
Positive samples (not quantifiable): 0
Quantifiable samples: 46
Limit of quantification: unknown
Limit of detection: 40

NPS_SARSCoV2

SARS-CoV-2 RNA gene copy concentration in nasopharyngeal samples. The results were reported in cycle threshold numbers.

Biomarker: SARS-CoV-2
Specimen: nasopharyngeal swab
Units: cycle threshold
Gene target: N
Participants: 12
Negative samples: 58
Positive samples (not quantifiable): 0
Quantifiable samples: 63
Limit of quantification: unknown
Limit of detection: 40

Urine_SARSCoV2

SARS-CoV-2 RNA gene copy concentration in urine samples. The results were reported in cycle threshold numbers.

Biomarker: SARS-CoV-2
Specimen: urine
Units: cycle threshold
Gene target: N
Participants: 10
Negative samples: 59
Positive samples (not quantifiable): 0
Quantifiable samples: 0
Limit of quantification: unknown
Limit of detection: 40