Clinical manifestations and viral kinetics of people with Mpox: A case series during the 2023 outbreak in Taiwan chen2024clinical

Case series from Taiwan (2023 mpox outbreak) reporting viral kinetics (PCR Ct values) across multiple specimen types (oropharyngeal/throat swab, vesicle swab, urethral swab, rectal swab) in mpox cases, including people with HIV and tecovirimat treatment. This extraction covers CSV batch 1/4 with repeated sampling per patient over days since a clinical reference timepoint (not specified in the provided excerpt).

Analytes

oropharyngeal_swab

Mpox virus DNA detection by PCR reported as cycle threshold (Ct) value from oropharyngeal (throat) swab (CSV rows where specimen=throat swab). Assay details (platform/gene target) not provided in the excerpted data.

exponential for oropharyngeal_swab

Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.

Biomarker: mpox
Specimen: oropharyngeal swab
Units: cycle threshold
Gene target: E9L
Participants: 14
Negative samples: 34
Positive samples (not quantifiable): 0
Quantifiable samples: 26
Limit of quantification: unknown
Limit of detection: 35

vesicle_swab

Mpox virus DNA detection by PCR reported as cycle threshold (Ct) value from vesicle swab. Assay details (platform/gene target) not provided in the excerpted data.

exponential for vesicle_swab

Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.

Biomarker: mpox
Specimen: vesicle swab
Units: cycle threshold
Gene target: E9L
Participants: 14
Negative samples: 23
Positive samples (not quantifiable): 0
Quantifiable samples: 37
Limit of quantification: unknown
Limit of detection: 35

urethra_swab

Mpox virus DNA detection by PCR reported as cycle threshold (Ct) value from urethral swab. Assay details (platform/gene target) not provided in the excerpted data.

gamma for urethra_swab

Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.

Biomarker: mpox
Specimen: urethral swab
Units: cycle threshold
Gene target: E9L
Participants: 14
Negative samples: 37
Positive samples (not quantifiable): 0
Quantifiable samples: 24
Limit of quantification: unknown
Limit of detection: 35

rectal_swab

Mpox virus DNA detection by PCR reported as cycle threshold (Ct) value from rectal swab. Assay details (platform/gene target) not provided in the excerpted data.

exponential for rectal_swab

Fitted by censored maximum likelihood. The red line is the median individual; the shaded region is the full range of a simulated cohort drawn from the fitted population, so it shows what simulating from this dataset would produce rather than a confidence interval, with dashed lines at the central 95%. Open triangles are non-detects, drawn at the censoring limit and entering the fit as "below this value" rather than being dropped. See the modelling methods for what these estimates do and do not support.

Biomarker: mpox
Specimen: rectal swab
Units: cycle threshold
Gene target: E9L
Participants: 14
Negative samples: 32
Positive samples (not quantifiable): 0
Quantifiable samples: 29
Limit of quantification: unknown
Limit of detection: 35