Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018 cantelli2020rotavirus
Prospective birth community-cohort study in Manguinhos, Rio de Janeiro, Brazil (2014–2018) following infants through <1 year of age who received Rotarix (RV1) oral rotavirus vaccine. Stool samples were collected and screened for rotavirus A shedding using RT-qPCR (Ct), with RV1 G1P[8] characterization and VP8* sequencing (including F167L mutation). This extraction captures individual Ct values and days post-vaccination (or pre-dose/non-vaccinated sampling) from the provided CSV/table for Le(a+b+) secretor children.
Analytes
1
Rotavirus A (vaccine-derived RV1 G1P[8]) RT-qPCR cycle threshold (Ct) values measured in stool samples collected after RV1 dose 1; positivity defined as Ct ≤ 40. Genotype/VP8* Sanger sequencing used to classify RV1 and F167L mutation status (reported separately in table/CSV as gene_type).
Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.
2
Rotavirus A (vaccine-derived RV1 G1P[8]) RT-qPCR cycle threshold (Ct) values measured in stool samples collected after RV1 dose 2; positivity defined as Ct ≤ 40. Genotype/VP8* Sanger sequencing used to classify RV1 and F167L mutation status (reported separately in table/CSV as gene_type).
Measurements only — no shedding model is fitted to this analyte, usually because it is sampled once per participant, leaving no trajectory to fit, or because nothing was ever detected. Open triangles are non-detects, drawn at the assay's censoring limit. See the modelling methods for what these estimates do and do not support.